Mass spectrometric method and MALDI-TOF mass spectrometer

摘要

There are a number of standard methods for normalizing MALDI-TOF data, but these can not adequately compensate for the observed technical variability. The invention provides an improved normalization method for MALDI-TOF mass spectrometry data. This is achieved by intensity profile normalization, where 1. an intensity profile is first formed for each individual spectrum, wherein the intensity profile describes the statistical distribution of the intensity values within different mass ranges, 2. Subsequently, a mean reference profile is formed for an ensemble of spectra, 3. Finally, the individual spectra are transformed so that their intensity profiles correspond to the reference profile.