A method of filtering a large volume of a medium with a pre-sterilizable, at least partially automated disposable filtration device

摘要

A method of filtering a large volume of a medium with a pre-sterilizable, at least partially automated disposable filtration device (10) comprising a non-filtrate inlet (56), a filtrate outlet (58), a main conduit extending between the non-filtrate inlet (56) and the filtrate outlet (58) , arranged in the main filter elements, a vent line (52) and sensors for detecting certain process parameters and control devices for setting certain process parameters, wherein the sensors and control devices with an external control and control system (78) are connected to the evaluation and processing of Sensor data as well as for controlling the control devices based on one or more control algorithms is set up, comprises the following process steps: a) filling the disposable filtration device (10) with medium with low flow; b) venting the disposable filtration device (10) through the vent line (52); c) closing the vent line (52); d) rinsing the disposable filtration device (10), in particular the filter elements; e) filtration of the medium by means of the filter elements; f) rinse with high flow; and g) closing the main line; wherein the process steps f) and g) are optional.