NANOVECTORS AND USES, ESPECIALLY FOR THE TREATMENT OF TUMORS

摘要

The present invention relates to the field of nanovectors for the delivery of active substances into the body, in particular for the treatment of tumors. These nanovectors are prepared by a process comprising the mixture of two solutions that can be administered in humans or animals: a. a first solution comprising nanoparticles, said nanoparticles being selected from nanoparticles based on polysiloxane, of average diameter less than 10 nm, preferably less than 5 nm, and b. a second solution comprising an active substance or a mixture of active substances chosen from organic molecules with a molecular weight of between 2 and 40% of the mass of said nanoparticle, preferably between 5 and and 25% of the mass of said nanoparticle, under conditions of concentration ratios, pH, and temperature allowing a physisorption interaction of the active substances on the surface of said nanoparticles. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in tumor tissues.