A system and method are presented for detecting and measuring pressure within a region of a body lumen or vessel. The pressure sensing system includes a light source for transmitting light through a pathway of fiber optic wire. A distal portion of the fiber optic wire is engaged to and extends along a guidewire. The distal portion of the fiber optic wire includes sensor station(s) made up of fiber Bragg gratings (FBG). The light transmitted to and reflected from the FBGs of the pressure sensing stations can be analyzed to provide one or more values.
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