BIOREACTOR SYSTEMS AND ASSOCIATED METHODS OF PROCESSING BIOREACTOR VESSELS

摘要

A bioreactor processing unit (10) includes at least one cell culture module (200) comprising: a base (202) including a receiving station (204) for removably receiving a plurality of bioreactor vessels (400) at respective locations (206); and a clamp plate (240). The clamp plate (240) is removably connectable to the base (202). The system further includes a drive mechanism (226) and multiple fluid conduits. When the system is to be used for an experiment run, vessels (400) are loaded into the receiving station (204) and the clamp plate (240) is connected to the base (202), forming a connection between the drive mechanism and the vessels, for transmitting input motion from the drive mechanism (226) into multiple rotary motion outputs for turning a stirrer (416) in each vessel (400). At the same time, connection of the clamp plate to the base forms a fluid connection between the multiple fluid conduits and an input port (412) in each respective vessel via associated multiple outlet ports (256) in the clamp plate and associated fluid connectors. The system further includes at least one sensor (126a, 126b) that is mounted so as to be movable to a position adjacent to each respective vessel location (206) for monitoring the contents of each vessel (400).