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DEVELOPMENT AND PARAMETER ASSESSMENT FOR VERTICALLY ALIGNED PLATINUM WIRE APTASENSOR ARRAYS FOR IMPEDIMETRIC DETECTION OF CARDIAC BIOMARKERS
DEVELOPMENT AND PARAMETER ASSESSMENT FOR VERTICALLY ALIGNED PLATINUM WIRE APTASENSOR ARRAYS FOR IMPEDIMETRIC DETECTION OF CARDIAC BIOMARKERS
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机译:垂直对齐的铂线适配体阵列的开发和参数评估,可用于心脏生物标志物的阻抗检测
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摘要
The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings.
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