EXPANDING THE HALOHYDRIN DEHALOGENASE ENZYME FAMILY: IDENTIFICATION OF NOVEL ENZYMES BY DATABASE MINING

摘要

The invention is related to a method for the identification of enzymes having potential halohydrin dehalogenase activity from sequences disclosed in a biomolecule database based on the use of characteristic amino acid sequence motifs. Additionally, the invention is related to the use of the identified halohydrin dehalogenases in the conversion of halohydrins into epoxides as well as to the use of the identified halohydrin dehalogenases in the conversion of epoxides into alcohols.