NORMALIZED CALIBRATION OF ANALYTE CONCENTRATION DETERMINATIONS

摘要

The invention relates to a method for calibrating a measurement device of a biosensor system, the method comprising: measuring at least two analyte responsive output signals, the analyte responsive output signals being affected by a primary stimulus in the form of a reference sample analyte concentration from a reference sample, and an extraneous stimulus resulting from one or more of a physical characteristic, an environmental aspect, or a manufacturing variation error incorporated into the analyte responsive output signals; determining, via a measurement device, a reference correlation by relating the primary stimulus to the two analyte responsive output signals; measuring, from the reference sample, an extraneous stimulus responsive output signal of the extraneous stimulus and quantifying the extraneous stimulus responsive output signal to provide at least two quantified extraneous stimulus values; determining a normalizing relationship from the analyte responsive output signals and the two quantified extraneous stimulus values, the normalizing relationship being determined at a single selected sample analyte concentration of the reference sample analyte concentrations; determining a normalized value from the normalizing relationship by inputting the quantified extraneous stimulus values into the normalizing relationship; dividing the analyte responsive output signals by the normalizing value to provide normalized analyte responsive output signals; and determining a normalized reference correlation between the two normalized analyte responsive output signals and the reference sample analyte concentrations by a regression technique, the normalized reference correlation providing a reduced stimulus effect in which the only variable between the primary stimulus and the extraneous stimulus is the primary stimulus.