PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED-1,2,4-OXADIAZOLES

摘要

Provided herein are processes for the preparation of 3,5-disubstituted-1,2,4-oxadiazoles and salts thereof comprising reacting a N-hydroxyamidine with an acyl chloride in a reaction mixture comprising a water-immiscible organic solvent and an aqueous base at relatively low reaction temperatures.