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SUBSTITUTED BERBINES AND THEIR SYNTHESIS
SUBSTITUTED BERBINES AND THEIR SYNTHESIS
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机译:取代的丁苯橡胶及其合成
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摘要
The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds preferably through a Bischler-Napieralski cyclization followed by reduction, as well as intermediates used in the synthesis of substituted berbine compounds. The amide precursor for the Bischler-Napieralski reaction could be obtained treating the free amine with acid halides, formate sources or aldehydes. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
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