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METHODS OF DETERMINING PROTEIN STRUCTURE USING TWO-PHOTON FLUORESCENCE MEASUREMENTS
METHODS OF DETERMINING PROTEIN STRUCTURE USING TWO-PHOTON FLUORESCENCE MEASUREMENTS
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机译:利用两光子荧光测定法测定蛋白质结构的方法
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摘要
Methods, devices, and systems for using two-photon fluorescence measurements, either alone or in combination with other nonlinear optical measurements such as second harmonic generation, sum frequency generation, or difference frequency generation, to determine structural parameters such as mean tilt angle and distribution width for tethered nonlinear-active biomolecules are described. The disclosed methods, devices, and systems may also be used to perform structural comparisons of two or more biomolecular samples; to detect changes in biomolecule conformation upon binding of a ligand; and to screen candidate binding partners to identify compounds that modulate the conformation of the biomolecule.
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