MODIFIED NATURAL KILLER CELLS AND NATURAL KILLER CELL LINES TARGETTING TUMOUR CELLS

摘要

NK cells and NK cell lines are modified to increase their selectivity for cancer cells by providing an ability to bind tumour associated MUC-1 antigen. Production of such modified NK cells and NK cell lines is via genetic modification to produce NK-CARs that are optionally further modified to have increased cytotoxicity against cancer cells.