首页> 外国专利> DYE FOR FLUORESCENT STAINING OF STRATUM CORNEUM, MANNER OF ITS SYNTHESIS AND APPLICATION IN MICROSCOPY, INCLUDING IDENTIFICATION OF ROUTES OF SUBSTANCES PENETRATION TO THE SKIN AND ASSESSMENT OF STRUCTURAL DISORDERS OF THIS LAYER

DYE FOR FLUORESCENT STAINING OF STRATUM CORNEUM, MANNER OF ITS SYNTHESIS AND APPLICATION IN MICROSCOPY, INCLUDING IDENTIFICATION OF ROUTES OF SUBSTANCES PENETRATION TO THE SKIN AND ASSESSMENT OF STRUCTURAL DISORDERS OF THIS LAYER

机译：角质层荧光染色染料，其合成方法及在显微镜下的应用，包括鉴定物质穿透皮肤的途径以及该层的结构紊乱的评估

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摘要

The subject of the invention are new derivatives of 1,2-dihydro-[1,2, 4]triazolo[4,3-a]quinolin-2-ium-4-carboxylic acid and the manner of their preparation;The subject of the invention is also the manner of obtaining fluorescent dye SAFQ8MeAKT and its application for stratum corneumstaining..

机译：本发明的主题是1,2-二氢-[1,2,4]三唑并[4,3- a ]喹啉-2-基-4-羧酸的新衍生物及其制备方法。他们的准备 <图像文件=“ IMGA0001.GIF” he =“ 40” imgContent =“ chem” imgFormat =“ GIF” wi =“ 139” /> ;本发明的主题是荧光染料SAFQ8MeAKT的制备方法及其在角质层染色中的应用。 展开▼

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公开/公告号EP3578559A1

专利类型

公开/公告日2019-12-11

原文格式PDF

申请/专利权人 GDANSKI UNIWERSYTET MEDYCZNY;
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申请/专利号EP20180020629

发明设计人 SACZEWSKI JAROSLAW HENRYK;PIENKOWSKA KRYSTYNA;KRENCZKOWSKA DOMINIKA;CAL KRZYSZTOF;FEDOROWICZ JOANNA;
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申请日2018-12-06

分类号C07D471/04;C09B57;C09B62/02;

国家 EP

入库时间 2022-08-21 11:39:44

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专利

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1. New dye for fluorescent dyeing of horny layer of epidermis (stratum corneum), method for obtaining it and its application in microscopy, including for identification of ways of penetration into skin and evaluation of structural disorders of that layer [P] . PL425847A1 . 2019-12-16

机译：用于表皮（角质层）的角质层荧光染色的新染料，获得该染料的方法及其在显微镜中的应用，包括鉴定渗透到皮肤的方式和评估该层的结构异常

2. THREE-DIMENSIONAL CULTURE OF IMMORTALIZED SKIN CELLS HAVING SUPERFICIAL LAYER FORMED FROM STRATUM CORNEUM, METHOD FOR PRODUCING SAID THREE-DIMENSIONAL CULTURE, AND METHOD FOR EVALUATING TEST SUBSTANCE USING SAID THREE-DIMENSIONAL CULTURE [P] . WO2021149761A1 . 2021-07-29

机译：具有由地层基层形成的浅层表面的永生皮细胞的三维培养，制备所述三维培养的方法，以及使用所述三维培养的测试物质的方法

3. Tetracyclic compounds produced by monocyclic and bicyclic carboxylic acids; cycloenzyme activators; pharmacological synthesis; useful substances for the treatment of cardiovascular and inflammatory diseases as well as liver, skin, kidney, lung and heart diseases, such as kidney disease and diabetes, Glaucoma, poliomyelitis, urinary disorders including bladder hypertension, benign proton hyperplasia, etc. [P] . CL2017000071A1 . 2017-06-30

机译：由单环和双环羧酸生成的四环化合物;环酶激活剂;药理合成用于治疗心血管和炎性疾病以及肝脏，皮肤，肾脏，肺和心脏疾病的有用物质，例如肾脏疾病和糖尿病，青光眼，小儿麻痹症，泌尿系统疾病，包括膀胱高血压，良性质子增生等。

1. Assessing skin barrier and stratum corneum surface integrity after application of skin cleansers on human skin by ex-vivo confocal laser scanning microscopy [J] . Galliano M., Carrasco C., Coubetergues H., The Journal of investigative dermatology. . 2018,第5a19期

2. Stratum corneum architecture of reconstructed human skin models monitored by fluorescent confocal laser scanning microscopy [J] . Kandarova H, Richter H, Liebsch M, Laser physics letters . 2007,第4期

3. Penetration of gold nanoparticles across the stratum corneum layer of thick-Skin [J] . Gayathri Raju, Neeraj Katiyar, Sajini Vadukumpully, Journal of dermatological science . 2018,第2期

4. Application of Single Molecule Fluorescence Microscopy to Characterize the Penetration of a Large Amphiphilic Molecule in the Stratum Corneum of Human Skin [O] . Pierre Volz, Alexander Boreham, Alexander Wolf, 2015

5. Application of Single Molecule Fluorescence Microscopy to Characterize the Penetration of a Large Amphiphilic Molecule in the Stratum Corneum of Human Skin [O] . Pierre Volz, Alexander Boreham, Alexander Wolf, 2015