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TARGETED MOSQUITOCIDAL TOXINS

机译:有针对性的灭蚊毒素

摘要

Insecticidal toxins described herein are fused toxin peptides made up of a targeting domain fused to a toxin domain. The targeting peptide generates a specific association with mosquitoes by causing the fused toxin peptide to bind mosquitoes in a way that leads to the insecticidal activity. Transgenic plants described herein are mosquitocidal by expressing an insecticidal toxin protein in nectar that includes a targeting peptide to ensure specificity against mosquitoes. These transgenic plants serve as role models for safety, since they are non-crop plants and specific to one mosquito species.
机译:本文所述的杀虫毒素是由与毒素结构域融合的靶向结构域组成的融合毒素肽。靶向肽通过使融合毒素肽以导致杀虫活性的方式结合蚊子而与蚊子产生特异性结合。本文所述的转基因植物通过在花蜜中表达杀虫毒素蛋白而被灭蚊,所述杀虫毒素蛋白包括靶向肽以确保对蚊子的特异性。这些转基因植物是安全性的榜样,因为它们是非农作物,并且对一种蚊子具有特异性。

著录项

  • 公开/公告号EP3607075A1

    专利类型

  • 公开/公告日2020-02-12

    原文格式PDF

  • 申请/专利权人 BAYLOR UNIVERSITY;

    申请/专利号EP20180719391

  • 发明设计人 KEARNEY CHRISTOPHER MICHEL;PRUETT GRACE;

    申请日2018-04-03

  • 分类号C12N15/82;A01N63;C07K14/18;C07K14/435;

  • 国家 EP

  • 入库时间 2022-08-21 11:39:34

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