ELASTIC MEMBRANE HAVING FUNCTION OF REACTIVATING ENDOMETRIUM BASAL LAYER IN UTERINE CAVITY AND PREPARATION METHOD FOR ELASTIC MEMBRANE

摘要

An elastic sheet with a function of re-activating an endometrial basal layer in a uterine cavity is provided. The elastic sheet comprises a silicone rubber and a drug, wherein the drug is encased inside the silicone rubber in the manner of a drug storage zone, or uniformly dispersed inside the silicone rubber, or carried by an outer surface of the silicone rubber as a coating, and the drug comprises an estrogen. A method for forming the elastic sheet is also provided. The method comprises of mixing, vulcanizing, crosslinking and solidifying a silicone rubber with a drug into a mixed sheet from the silicone rubber and drug to form a matrix-type elastic sheet; or dissolving the drug and a degradable polymer in a solvent to form a drug solution, and then spraying the drug solution onto the silicone rubber to form a sustained release coating. According to the present invention, the estrogen is loaded on the silicone rubber, and thus the endometrial basal layer is continuously activated through drug stimulation, allowing for the endometrial basal layer to re-proliferate the functional layers, thereby restoring the normal endometrial structure and completely preventing adhesions.