Aspects of the application related to methods, a computer program and a process control device. According to one aspect, a computer-implemented method for determining a multivariate process chart is provided. The multivariate process chart is to be used to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product. The multivariate process chart includes a first trajectory, an upper limit for the first trajectory and a lower limit for the first trajectory. The method comprises providing a plurality of first-scale vessels, each of the first-scale vessels containing fluid for producing the product. The method further comprises receiving, by a first process control device, process parameters, the process parameters including process parameters to be controlled and process parameters to be measured. The method further comprises controlling, by the first process control device and at least partly in parallel, the process in each of the first-scale vessels. The method further comprises periodically determining, at least in part by the first process control device, process parameter values for the process parameters from the fluid in each of the first-scale vessels. The method further comprises defining groups of the process parameter values according to a common characteristic, wherein each of the groups includes process parameter values determined from multiple ones of the first-scale vessels. The method further comprises determining at least one statistically representative value for each of the groups of process parameter values. The method further comprises establishing the first trajectory from the statistically representative values. The method further comprises determining the upper limit and the lower limit based on a measure of variation within each group.
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