METHOD FOR PRODUCING LIVER STEM CELLS OR LIVER PROGENITOR CELLS BY DIRECT REPROGRAMMING

摘要

A method for inducing conversion from non-hepatic stem cells or non-hepatic progenitor cells into hepatic stem cells or hepatic progenitor cells, which comprises introducing any of the following combinations into the non-hepatic stem cells or non-hepatic progenitor cells:(a) a combination of HNF1, HNF6 and FOXA;(b) a combination of HNF1 gene, HNF6 gene and FOXA gene;(c) a combination of HNF1, MYC and FOXA; or(d) a combination of HNF1 gene, MYC gene and FOXA gene.