首页>
外国专利>
LIGAND BINDING ASSAYS USING MALDI-TOF MASS SPECTROMETRY
LIGAND BINDING ASSAYS USING MALDI-TOF MASS SPECTROMETRY
展开▼
机译:MALDI-TOF质谱法进行配体结合测定
展开▼
页面导航
摘要
著录项
相似文献
摘要
An apparatus for ligand binding assays includes an incubator that incubates a plurality of beads with a sample of interest wherein each of the plurality of beads comprises a tag of predetermined mass and a bait molecule. A washer washes the incubated beads so that weakly bound molecules are removed while strongly bound molecules are retained. A sample plate loader loads the washed beads into the sample plate such that respective ones of the plurality of beads are loaded into respective ones of the plurality of well. A sprayer deposits matrix assisted laser desorption ionization (MALDI) matrix material on the surface of the sample plate so that each of the plurality of beads is exposed to MALDI matrix material. A MALDI-TOF mass spectrometer receives the sample plate and performs mass spectrometry on samples in the plurality of wells. A computer executes an algorithm that analyzes the mass spectra.
展开▼