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NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER INCLUDING NSCLC

机译:针对多种肿瘤的新型免疫疗法,例如包括NSCLC的肺癌

摘要

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to more than 70 novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
机译:本发明涉及用于免疫治疗方法的肽,核酸和细胞。特别地,本发明涉及癌症的免疫疗法。本发明还涉及单独或与其他肿瘤相关肽组合的肿瘤相关细胞毒性T细胞(CTL)肽表位,其充当刺激抗肿瘤免疫反应的疫苗组合物的活性药物成分。本发明涉及可从人肿瘤细胞的HLA I类和HLA II类分子中衍生的70多种新颖肽序列及其变体,它们可用于疫苗组合物中以引发抗肿瘤免疫应答。

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