Method for producing adult hepatic progenitor cells

摘要

PROBLEM TO BE SOLVED: To provide an isolated cell population containing a novel adult liver progenitor cell (referred to as H2Stem Cell), and a composition containing the isolated cell population. At a minimum, (a) α-smooth muscle actin (ASMA), albumin (ALB), and CD140b are positive, (b) Sushi domain-containing protein 2 (SUSD2) and cytokeratin-19 (CK-). Negative to 19), positive for at least one liver marker selected from (c) albumin, HNF-3B, HNF-4, CYP1A2, CYP2C9, CYP2E1 and CYP3A4, (d) vimentin, An isolated cell population comprising adult hepatic progenitor cells, characterized in that cells are measured as positive for at least one mesenchymal marker selected from CD90, CD73, CD44 and CD29. [Selection diagram] None