To provide appropriate systems and methods for determination of blood flow characteristics and pathologies through modeling of myocardial blood supply.SOLUTION: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes: receiving one or more vascular models 201 associated with either the patient or with a plurality of individuals; receiving observed perfusion information 203 associated with the patient; and using one or more computer processors to estimate one or more blood flow characteristics or one or more pathological characteristics 209 of the patient on the basis of the observed perfusion information and the one or more vascular models 205.SELECTED DRAWING: Figure 2A
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