ENGINEERED HIGH-AFFINITY HUMAN T CELL RECEPTORS

摘要

To provide T cell receptors (TCRs) that have specificity for the WT1 antigen.SOLUTION: The TCRs include higher affinity TCRs that have been engineered through generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e., directed evolution). In embodiments, the TCRs can be used in a soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.SELECTED DRAWING: None