Bile duct cell proliferation method

摘要

The present invention relates to the proliferation of primary cholangiocyte cells in the form of cholangiocyte organoids (CO) using culture conditions in which classical Wnt signaling is inhibited and non-classical Wnt/PCP signaling is enhanced. Methods of expanding primary cholangiocytes, populations of expanded cholangiocytes and medical uses of expanded cholangiocytes are provided. [Selection diagram] None