A new way to predict the risk of transplant rejection

摘要

In the field of transplant rejection, SNPs have been identified in which mismatches in recipient and donor variants of SNPs are predictors of transplant outcome, and these SNPs are newly associated non-HLA loci associated with rejection. Corresponds to. The present invention predicts transplant outcomes, such as increased risk of antibody-mediated rejection, increased risk of T cell-mediated rejection, or low risk of rejection, by analyzing mismatches between donors and recipients for the listed SNPs. be able to. Specific of the listed SNPs are predictors of kidney transplant outcomes. Predictive donor suitability can be evaluated against the recipient and optimized donor-recipient pairing can be enabled.