Treatment of heart disease by inhibiting the action of muscle A-kinase anchor protein (mAKAP)

摘要

The present invention provides a method of protecting the heart from injury, wherein the method comprises a pharmaceutically effective amount of a composition that inhibits the interaction of RSK3 with mAKAPβ, or the expression or activity of one or both of those molecules. It is performed by administration to patients at risk of injury. The composition is preferably in the form of a siRNA construct that inhibits the expression of mAKAPβ, more preferably a shRNA construct. [Selection diagram] FIG. 7