MATRIX METALLOPROTEINASE SUBSTRATES AND OTHER CLEAVABLE MOIETIES, AND METHODS OF USE THEREOF

摘要

To identify new substrates for proteases and use these substrates for a variety of therapeutic, diagnostic and prophylactic applications.SOLUTION: The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other large molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease and using them for a variety of therapeutic, diagnostic and prophylactic applications.SELECTED DRAWING: Figure 1A