Anticancer composition comprising tumor-specific killing adenovirus and immune checkpoint inhibitor

摘要

The present invention relates to an anticancer composition comprising a tumor-specific killing adenovirus and an immune checkpoint inhibitor. The recombinant adenovirus of the present invention, into which IL-12 and shVEGF, or IL-12 and GM-CSF-Relaxin have been introduced, exhibits an excellent anticancer effect by improving the immune function, and exhibits such an anticancer effect. Has been confirmed to be significantly enhanced through the combined use with an immune checkpoint inhibitor. Therefore, the present invention can be utilized as a core technology in the field of cancer treatment.