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Methods of using low dose volume B cell epitope compositions to induce an antibody immune response in a human subject

机译:使用低剂量体积B细胞表位组合物在人类受试者中诱导抗体免疫反应的方法

摘要

The present disclosure provides methods, uses and compositions and kits for use in inducing an antibody immune response in a human subject. The methods and uses include parenterally administering a low dose volume of a composition comprising an antigen comprising a B cell epitope, an amphiphilic compound, and a hydrophobic carrier, wherein the composition is administered at a low dose. The volume is less than 100 μl and induces an antibody immune response against B cell epitopes in human subjects. [Selection] Figure 1
机译:本公开提供了用于在人受试者中诱导抗体免疫应答的方法,用途,组合物和试剂盒。所述方法和用途包括肠胃外施用低剂量体积的包含抗原的组合物,所述抗原包含B细胞表位,两亲化合物和疏水性载体,其中所述组合物以低剂量施用。该体积小于100μl,并且在人受试者中诱导针对B细胞表位的抗体免疫应答。 [选择]图1

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