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Extracellular matrix (ECM) hydrogels for treating cancer and soluble fractions thereof
Extracellular matrix (ECM) hydrogels for treating cancer and soluble fractions thereof
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机译:用于治疗癌症的细胞外基质(ECM)水凝胶及其可溶性级分
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摘要
Disclosed are methods for reducing tumor cell proliferation, increasing tumor cell apoptosis, and / or reducing tumor cell migration. These methods include contacting the tumor cells with an effective amount of a solubilized ECM or soluble fraction of an extracellular matrix (ECM), thereby reducing tumor cell proliferation, increasing tumor cell apoptosis, And / or reducing migration of tumor cells. Also disclosed are methods for treating a subject having a tumor. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a soluble fraction of ECM and a pharmaceutically acceptable carrier, thereby treating a tumor in the subject. Is included. In a specific, non-limiting example, the tumor is a glioma and / or the ECM hydrogel is a bladder ECM hydrogel.
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