Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof

摘要

Provided herein are recombinant fusion polypeptides that include one or more antigenic peptides derived from a cancer-associated protein (eg, fused to a PEST-containing peptide). Antigenic peptides can include one or more or all of an antigenic peptide containing a recurrent cancer mutation, an antigenic peptide containing a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, a recombinant fusion polypeptide comprising two or more antigenic peptides (eg, fused to a PEST-containing peptide), each antigenic peptide containing a recurrent cancer mutation. Provided herein are recombinant fusion polypeptides in which at least two of the sex peptides are fragments of the same cancer-associated protein.