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Urate transporter inhibitor sodium salt and its crystalline form

机译:尿酸盐转运蛋白抑制剂钠盐及其结晶形式

摘要

The present invention relates to a sodium salt of a uric acid transporter inhibitor and the crystalline form thereof. In particular, the present invention relates to the sodium salt of a uric acid transporter (URAT1) inhibitor, and the I-type crystal and the preparation method thereof. The present invention relates to 1-((6-bromo-quinoline-4-yl)thio)cyclobutyl sodium formate (the compound of formula (I)), and the I-type crystal and the preparation method thereof. The I-type crystal of the compound of formula (I) obtained in the present invention has a good crystal form stability and chemical stability, and the crystallization solvent used has a low toxicity and low residue, and can be better used in clinical treatment.
机译:尿酸转运蛋白抑制剂的钠盐及其结晶形式本发明涉及尿酸转运蛋白抑制剂的钠盐及其结晶形式。特别地,本发明涉及尿酸转运蛋白(URAT1)抑制剂的钠盐,I型晶体及其制备方法。本发明涉及1-((6-溴-喹啉-4-基)硫代)环丁基甲酸钠(式(I)的化合物)和I型晶体及其制备方法。在本发明中获得的式(I)的化合物的I型晶体具有良好的晶形稳定性和化学稳定性,并且所使用的结晶溶剂具有低毒性和低残留物,并且可以更好地用于临床治疗。

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