HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING

摘要

PROBLEM TO BE SOLVED: To provide methods and devices for producing cavitation in tissue.;SOLUTION: A shock scattering method of Histotripsy therapy comprises: delivering an initiation pressure waveform from an ultrasound therapy transducer 102 into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue; delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble; and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. The scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2020,JPO&INPIT