Acid-resistant and sustained-release oral probiotic spherical tablets

摘要

PROBLEM TO BE SOLVED: To provide an oral probiotic spherical tablet for oral use, which has a multi-layer coating structure to improve environmental resistance and stability, has resistance to acids, bile salts, pancreatic juice, etc. in the digestive tract and can be mass-produced at low cost. To do. SOLUTION: An acid-resistant and sustained-release oral probiotic spherical tablet comprises a core 1 containing probiotics, a protective layer 2 covering the outside of the core 1, and a sustained-release layer 3 covering the outside of the protective layer 2. And a bile salt-resistant pancreatic juice layer 4 which covers the outer side of the sustained-release layer 3, an acid resistant layer 5 which covers the outer side of the bile salt pancreatic juice layer 4, and an isolation layer 6 which covers the outer side of the acid resistant layer 5. The core 1 containing probiotics is molded into a spherical core. [Selection diagram] Figure 1