COMPOSITIONS AND KITS USEFUL IN DIAGNOSIS/PROGNOSIS/ASSESSMENT OF BRAIN INJURIES

摘要

To provide compositions and methods useful in the diagnosis/prognosis/assessment of brain injuries.SOLUTION: A method for identifying which patients with traumatic brain injury (TBI) require a head computerized tomography (CT) scan for diagnosing acute intracranial pathology, comprises the steps of: (a) obtaining or collecting a sample from the patient; (b) measuring the levels of one or more biomarkers in the blood sample obtained from the patient, in which step the biomarkers comprise glial fibrillary acidic protein (GFAP), S100B, metallothionein 3 (MT3), neuron specific enolase (NSE) and intracellular adhesion molecule 5 (ICAM5); and (c) identifying the patient as requiring or not requiring a head CT scan on the basis of the measured levels of one or more of biomarkers comprising GFAP, S100B, MT3, NSE, and ICAM5.SELECTED DRAWING: Figure 1