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MONO- AND DI-PEG IL-10 PRODUCTION AND USES
MONO- AND DI-PEG IL-10 PRODUCTION AND USES
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机译:单和双-PEG IL-10的生产和用途
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摘要
PROBLEM TO BE SOLVED: To provide methods of producing mono- and di-pegylated IL-10.;SOLUTION: A method comprises producing a mixture of mono-pegylated IL-10 and di-pegylated IL-10 by reacting IL-10 with an activated PEG-linker in the presence of a reducing agent. The activated PEG-linker is selected from the group consisting of succinimidylcarbonate-PEG, PEG-butyraldehyde, PEG-pentaldehyde, PEG-amido-propionaldehyde, PEG-urethano-propioaldehyde, and PEG-propylaldehyde. The reducing agent is selected from the group consisting of borohydride, sodium cyanoborohydride, amine borane, and picoline borane. The IL-10 and the reducing agent are present with a molar ratio from 0.0009 to 0.04.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2020,JPO&INPIT
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