Enhancer of cell predation for use in sensitizing tumors to radiation therapy

摘要

The present invention relates to the use of the compounds shown in Tables 1 and 2 and analogs thereof for promoting IR media cell phagocytosis in cancer cells. The compounds are referred to herein as "promoters of IR media cell phagocytosis." The compounds can be used to enhance tumor immunogenicity and / or induce a significant protective anti-cancer immune response in a subject that will or will receive radiation therapy. In other words, the compounds can be used to enhance radiation therapy in a subject in need thereof. The compound is preferably mebuhiroline 1,5-naphthalenedisulfonic acid salt, flurbiprofen, minaprine dihydrochloride, myricetin, digoxin, digitoxin, lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450 and VP43. Selected from the group consisting of: