Tumor selective TATA box and CAAT box variants

摘要

The present invention provides, for example, a recombinant virus comprising (i) a modified TATA box-based promoter and / or (ii) a modified CAAT box-based promoter operably linked to a gene, wherein the modified TATA box is provided. The system promoter and / or the modified CAAT box system promoter lacks a functional TATA box and / or CAAT box, allowing selective expression of the gene in hyperproliferative cells. The recombinant virus can be used to treat cell proliferative diseases and disorders, including certain forms of cancer.