Lentiviruses and non-integrating lentiviruses as viral vectors for delivering CRISPR therapeutics

摘要

A lysogen comprising a lentiviral vector encoding an isolated nucleic acid encoding two or more gene editors selected from gene editors targeting viral DNA, gene editors targeting viral RNA, and combinations thereof. A composition for treating a virus. A composition for treating lytic virus, comprising at least one gene editor targeting viral DNA and a lentiviral vector encoding an isolated nucleic acid encoding a viral RNA targeting composition. A composition for treating both lysogenic and lytic viruses, comprising a lentiviral vector encoding an isolated nucleic acid encoding two or more gene editors targeting viral RNA. A composition for treating a lytic virus. A method for treating a lysogenic or lysed virus by administering the above composition to an individual having the virus and inactivating the virus. [Selection diagram] Fig. 1