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Fused cyclic pyrimidine compounds as dual inhibitors of BRAD4 and JAK2 and methods for their use

机译:融合的环状嘧啶化合物作为BRAD4和JAK2的双重抑制剂及其使用方法

摘要

The present invention relates to fused cyclic pyrimidine compounds, in particular pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, methods of inhibiting BRAD4 and / or JAK2, and various compounds such as cancer and leukemia. Methods for treating diseases and conditions. Includes bromodomain binding and JAK activity. [Selection diagram] None
机译:本发明涉及稠合的环状嘧啶化合物,特别是吡咯并嘧啶和硫代嘧啶化合物及其衍生物,其药物组合物,抑制BRAD4和/或JAK2的方法,以及各种化合物,例如癌症和白血病。治疗疾病和状况的方法。包括bromodomain绑定和JAK活动。 [选择图]无

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