Medical use of artemisinin derivatives in the treatment of inflammatory bowel disease

摘要

The present invention provides use of the artemisinin derivative or a pharmaceutically acceptable salt thereof for producing a medicament for treating or adjunct treatment of inflammatory bowel disease. As a result of an experimental study of the artemisinin derivative of the present invention or a pharmaceutically acceptable salt thereof in a mouse animal model of dextran sulfate (DSS) -induced inflammatory bowel disease, intragastric administration resulted in weight loss, diarrhea of experimental animals, Effectively ameliorate the clinical symptoms of ulcerative colitis, such as blood in stool, reduce the pathological damage of colon tissue, suppress the infiltration of inflammatory cells into colon tissue, and the associated proinflammatory It was demonstrated that the levels of cytokines can be downregulated. Pharmacological and pharmacological studies show that such compounds have good immunosuppressive activity and high safety, and have excellent prospects as pharmaceuticals and medical uses for the treatment and auxiliary treatment of inflammatory bowel disease. .