Methods of administering neurosteroids to provide electroencephalogram (EEG) burst suppression

摘要

The disclosure of the present application comprises nanoparticles of a neurosteroid having a D50 of less than 2 μm and a polymer surface stabilizer selected from hydroxyethyl starch, dextran and povidone, wherein 0.1 to 50 mg of nerve per kg body weight of the patient Disclosed is a method for inducing EEG burst suppression or EEG suppression in a patient, comprising administering to the patient a formulation comprising a steroid. Neurosteroids can be administered intravenously, intramuscularly, subcutaneously or orally. Intravenous, intramuscular, subcutaneous or oral administration of a continuous bolus dose containing 0.5 mg ganaxolone / kg of the patient's body weight at successive intravenous administrations and at intervals of less than 30 minutes between two consecutive administrations. Is included in the disclosure of the present application. [Selection] FIG. 4A