MOLECULAR VARIANT ADIPONECTIN AND PHARMACEUTICAL COMPOSITION COMPRISING MOLECULAR VARIANT ADIPONECTIN

摘要

To provide a molecular variant adiponectin which is produced as a uniform product without mixing trimer, hexamer, 12-18 mer, etc., and has an activity equivalent to or higher than that of natural adiponectin.SOLUTION: There is provided a molecular variant adiponectin which is converted to a fusion protein comprising a trimerization domain such as a coiled-coil domain of a matriline family protein and a globular region of adiponectin so as to naturally associate and form a uniform trimer. There is provided a molecular variant adiponectin further comprises ZZ domain of protein A of Staphylococcus (staphylococcus), in which the ZZ domain of protein A is located on the N-terminal side of the coiled-coil region of the matriline.SELECTED DRAWING: Figure 1