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Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease

机译:四氢萘啶,苯并恶嗪,氮杂-苯并恶嗪和相关双环化合物用于抑制RORγ活性和治疗疾病

摘要

The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.; embedded image
机译:本发明提供了某些式(I)的双环杂环化合物或其药学上可接受的盐,其中X 1 ,X 2 ,R 1 , R 2 ,R 3 ,R4和Cy如本文所定义。本发明还提供了包含式(I)化合物或其药学上可接受的盐的药物组合物,以及使用式(I)化合物或其药学上可接受的盐或包含该化合物的药物组合物治疗介导的疾病或病症的方法通过RORgammaT。 “嵌入式图像”

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