H3C—(CH2)n—CHmCHmR,where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound."/>
Induction of a physiological dispersion response in bacterial cells in a biofilm
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Induction of a physiological dispersion response in bacterial cells in a biofilm
Induction of a physiological dispersion response in bacterial cells in a biofilm
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机译:诱导生物膜中细菌细胞中的生理分散反应
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摘要
One aspect of the present invention is directed to a composition. The composition includes a dispersion inducer comprising:H3C—(CH2)n—CHmCHmR,where is a single or double carbon-carbon bond, m is 1 or 2, n is 2 to 15, and R is a carboxylic acid, a salt, an ester, or an amide, where the ester or amide is an isostere or biostere of the carboxylic acid. The composition additionally contains an additive component selected from one or more of the group consisting of biocides, surfactants, antibiotics, antiseptics, detergents, chelating agents, virulence factor inhibitors, gels, polymers, pastes, edible products, and chewable products. The composition is formulated so that when it is contacted with a biofilm produced by a microorganism, where the biofilm comprises a matrix and microorganism on a surface, the dispersion inducer selectively acts on the microorganism and has a suitable biological response without a required direct effect on the matrix to disperse the biofilm. The present invention is also directed to methods of using this compound.
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机译:本发明的一个方面涉及一种组合物。该组合物包括分散诱导剂,其包括:<?in-line-formulae description =“在线公式” end =“ lead”?> H 3 Sub> C-(CH 2 Sub>) n Sub>-CH m Sub> CH m Sub> R,<?in-line-formulae description =”在线表达式“ end =” tail“?>其中是一个或两个碳素-碳键,m为1或2,n为2至15,并且R为羧酸,盐,酯或酰胺,其中该酯或酰胺为羧酸的等排或生物甾。该组合物还包含选自生物杀伤剂,表面活性剂,抗生素,防腐剂,清洁剂,螯合剂,毒力因子抑制剂,凝胶,聚合物,糊剂,可食用产品和可咀嚼产品中的一种或多种的添加剂组分。配制该组合物,使得当其与由微生物产生的生物膜接触时,其中生物膜在表面上包含基质和微生物,该分散诱导剂选择性地作用于微生物并具有合适的生物反应,而无需对生物膜直接作用。基质以分散生物膜。本发明还涉及使用该化合物的方法。
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