首页>
外国专利>
Animal models, cell lines and methods for screening hepatitis C virus vaccines
Animal models, cell lines and methods for screening hepatitis C virus vaccines
展开▼
机译:筛选丙型肝炎病毒疫苗的动物模型,细胞系和方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Modified non-human mammalian hepatoma cell lines that express hepatitis C virus (HCV) antigens and which are capable of generating tumours in a syngeneic animal model are provided. The cell lines are generated by genomic integration of an expression construct that comprises one or more HCV antigen-encoding sequences under the control of a constitutive promoter. The expression construct further comprises a selectable marker and a reporter gene under the control of the same promoter. The cell lines are useful for testing prophylactic and therapeutic vaccines against HCV either in vitro or in vivo.
展开▼