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Fibronectin type III domain proteins with enhanced solubility
Fibronectin type III domain proteins with enhanced solubility
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机译:具有增加的溶解度的纤连蛋白III型域蛋白
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摘要
Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.
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机译:本文提供了包含修饰的III型纤连蛋白(Fn3)结构域的多肽,其中对应于SEQ ID NO:1的残基58的氨基酸被突变,并且其中相对于其中氨基的Fn3结构域的溶解度而言,其溶解度提高了。对应于SEQ ID NO:1的残基58的氨基酸没有突变。还提供了包含多个多肽的文库以及用于鉴定与靶标结合的多肽的方法。
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