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Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
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机译:修饰的细菌具有改善的药代动力学和肿瘤定植,可增强抗肿瘤活性
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摘要
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat, inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or tryptophanase. The bacteria may have improved serum half-life, increased penetration into tumors, increased tumor targeting and increased antitumor activity. The bacteria are useful for delivery of therapeutic agents that treat of neoplastic diseases including solid tumors and lymphomas.
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