In vivo differentiation of relative oxygen levels and tumor necrosis using divalent europium

摘要

A method of magnetic resonance imaging a target tissue in a subject includes a step of administering a first Eu²⁺-containing complex to the subject. The first Eu²⁺-containing complex has a reduction potential that is more negative than a reduction potential for a selected compound present in the target tissue. A first set of images of the target tissue in the subject is then taken by T₁-weighted magnetic resonance imaging.