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Method for preparing a three-dimensional polymer scaffold for tissue engineering
Method for preparing a three-dimensional polymer scaffold for tissue engineering
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机译:用于组织工程的三维聚合物支架的制备方法
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摘要
A method for preparing a three-dimensional polymer scaffold (3D-PS) for use in tissue-engineering, the method including the subsequent steps of: providing a polymeric precursor scaffold (p-PS) having at least one biodegradable natural polymer (PA); treating the polymeric precursor scaffold (p-PS) with a cross-linking agent having glutaraldehyde to induce cross-linking of the natural polymer (PA), thereby forming a cross-linked polymer scaffold (x-PS) and subjecting the cross-linked polymer scaffold (x-PS) of step b) to low-pressure plasma treatment involving exposure of the polymer scaffold to an ionized oxygen-containing gas plasma at a pressure in the range of 10−3 to 10−6 bar and a temperature below 40° C.
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机译:一种制备用于组织工程的三维聚合物支架(3D-PS)的方法,该方法包括以下步骤:提供一种具有至少一种可生物降解的天然聚合物(P < Sub> A Sub>);用具有戊二醛的交联剂处理聚合物前体支架(p-PS),以诱导天然聚合物(P A Sub>)交联,从而形成交联的聚合物支架(x- PS)并使步骤b)的交联聚合物支架(x-PS)经受低压等离子体处理,包括将聚合物支架在10Sup的压力下暴露于电离的含氧气体等离子体中−3 Sup>至10 −6 Sup> bar,温度低于40°C。
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