首页>
外国专利>
Method for improving the stability of purified factor VIII after reconstitution
Method for improving the stability of purified factor VIII after reconstitution
展开▼
机译:重构后提高纯化的factor因子稳定性的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present disclosure relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising essentially the A1 domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing the Factor VIII molecule. The disclosure further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non-intravenous injection.
展开▼